The historical markers were designed and installed in 2001 to establish a sense of significance to important pieces of Iowa State University's history. The signs also inform visitors, students, and the campus community about significant accomplishments of national or international importance.

| Marker | Location |
|---|---|
| A Faster Fax | Southeast of Coover Hall |
| Birthplace of Cooperative Extension | North of Curtiss Hall |
| Birthplace of the Computer | South of Physics Hall |
| Campaniling | Campanile |
| Chemical Analysis Innovation | South of Gilman Hall |
| Finest Blue Cheese | West of Food Science Building |
| First Ag Engineering Degree | Southwest of Davidson Hall |
| First Artist-in-Residence | South of Mackay Hall |
| First Land Grant | North of Beardshear |
| First Land-Grant Home Economics College | North of Mackay Hall |
| First Statistical Laboratory | North of Snedecor Hall |
| First Veterinary Medicine College | South of Lagomarcino Hall |
| First Veterinary Medicine College | South of Vet Med Plaza |
| First Water Tower | East side of Water Tower |
| Innovative Baler | Southeast of Davidson Hall |
| Largest Grant Wood Murals | Southeast corner of Parks Library |
| Largest Student-Organized Festival | South Central Campus |
| Pure Uranium | North of Wilhelm Hall |
To view a map of all the items inventoried, go to the Online Campus Map.